Biochemistry of the Paleo Diet


doug mcguff mdDoug McGuff, MD became interested in exercise at the age of 15 when he first read Arthur Jones’ Nautilus Training Bulletin No. 2. His interest in exercise and biology led him into a career in medicine. In 1989, he graduated from the University of Texas Medical School at San Antonio and went on to train in Emergency Medicine at the University of Arkansas for Medical Sciences at Little Rock where he served as Chief Resident. From there, Dr. McGuff served as Faculty in the Wright State University Emergency Medicine Residency and was a staff Emergency Physician at Wright-Patterson AFB Hospital.

Throughout his career Dr. McGuff maintained his interest in high intensity exercise. Doug realized a lifelong dream when he opened Ultimate Exercise in November, 1997. Over the past 13 years Dr. McGuff and his instructors have continued to explore the limits of exercise through their personal training clients at Ultimate Exercise.

In addition to his work at Ultimate Exercise, Dr. McGuff is a partner with Blue Ridge Emergency Physicians, P.A. Dr. McGuff Lives in Seneca, South Carolina with his wife of 25-years, and their Children Eric and Madeline.

Doug is the best selling co-author of Body by Science and The Body by Science Question and Answer Book.


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  1. Karthik says:

    Awesome…. The Dr is one person who literally changed my life. Sounds too similar to what you said, but its true. Couldn’t put it better-“Champions of Exercise”. I just wish I were 21 when I heard all this. Wouldn’t have taken this long to actualize my goals. Thanks for the efforts to bring in speakers of such knowledge and caliber.

  2. I’ve been following this protocol for a while and it’s awesome. I also highly recommend the book which is fantastic and very well founded. FYI I’ve done an Spanish review of it here:

  3. Tim Horine says:

    Doug McGuff’s Big 5 Protocol, along with Mark Sisson’s Primal blueprint diet= loss of over 12 lbs of pure fat, and I went from 20.15% bodyfat to 11.50% bodyfat. Now, it took me about 9 months, but results take time, patience, and the key ingredient that both of these men provide: Truth.

    If you want to have the healthiest body, lose fat, and gain muscle simultaneously, then there is no better option than to buy both of the books from Doug McGuff and Mark Sisson.

    But, you must remember that it will take dedication and time, and if you follow their advice and apply it to your choices in diet and exercise, I promise that you will see results.

    before you begin: get a bodyfat % measurement and weight, and measure your limbs and torso, and you will get results.

    Listen to everything these men have to say, cause it will save your life, literally, and make you as physically attractive as possible.

  4. NomadicNeill says:

    Anthony, I’ve criticized you in the past for speaking about things that you weren’t qualified to IMO and for telling people to listen to ‘experts’ whom I know to be fakes.

    But I want to congratulate and thank your for bringing the paleo / primal way to a wider audience.

    Everyone should know the real way to get and stay healthy.

    Good luck with your conventions this year.

  5. DP says:

    Sheer genius, wow that was an awesome speech. It was so informative and interesting all at once. Doug really knows things on a deep level and I love how he is able to convey even the most technical biological processes with such clarity.

  6. Goran says:

    Its so funny, I hear guys all the time telling me, you have to work out 3 times a week or theres no point, and then when they have taken a week off from working out they get back to me and say “Hahaha, isnt it funny how you take a week off from working out and you come back stronger.” And then they go back to working out 3 times a week.

    They cannot link the two togehter, its ridiculous, but then again I used to be like that.

  7. Enrick says:

    can you please tell me list of foods that can give a lot of energy but is good for people who are on a diet?